La Ermita Church is a Catholic Church that was originally built in the early 17th century as a straw-colored structure dedicated to Our Lady of Solitude and the Lord of Caña. The church we see today was rebuilt in 1942 due to the earthquake in 1925, and it is now one of Cali City's architectural landscape landmarks. The current structure is a small Neo-Gothic church inspired by Ulm Cathedral in Germany, as are many Neo-Gothic churches in America. The new hermitage is dedicated to Our Lady of Sorrows. The old image of the Lord of the Caa on the left side altar is preserved.

The Plaza de Caicedo is the city's main square. During colonial times, it was known as La Plaza Mayor until 1813, when it was renamed Plaza de la Constitución. It is surrounded by numerous buildings, the most notable of which is the National Palace. Followed by the Otero Building and the San Pedro Cathedral, both listed as national monuments alongside the square.

The Calima Gold Museum, located in the historic center of Santiago de Cali, Colombia, is an archaeological museum dedicated to the Calima culture. It was the ninth museum established by the Bank of the Republic of Colombia to exhibit pre-Hispanic artistic and cultural expressions. It is also one of the Bank's six gold museums spread across Colombia.

The Chapel of San Antonio is a Catholic Church in baroque style that is located on the Hill of San Antonio in Cali. It is dedicated to San Antonio de Padua, frequented by the faithful for mass on Sundays and holidays.

The Tertulia Museum is a modern art museum with the country's most extensive collection of works on paper. It houses a significant American and Colombian art collection, particularly graphic work. It is displayed in a building dedicated to permanent exhibitions, where modern and contemporary art exhibitions are constantly held in its rooms.