Ephesus was an ancient Greek city on the coast of Ionia, three kilometres southwest of present-day Selçuk in İzmir Province, Turkey. It was built in the 10th century BC on the site of the former Arzawan capital by Attic and Ionian Greek colonists. During the Classical Greek era it was one of the twelve cities of the Ionian League. The city flourished after it came under the control of the Roman Republic in 129 BC. The city was famed for the nearby Temple of Artemis (completed around 550 BC), one of the Seven Wonders of the Ancient World. Among many other monumental buildings are the Library of Celsus, and a theatre capable of holding 25,000 spectators. Ephesus was one of the seven churches of Asia that are cited in the Book of Revelation. The Gospel of John may have been written here. The city was the site of several 5th-century Christian Councils (see Council of Ephesus). The city was destroyed by the Goths in 263, and although rebuilt, the city's importance as a commercial centre declined as the harbour was slowly silted up by the Küçükmenderes River. It was partially destroyed by an earthquake in AD 614. The ruins of Ephesus are a favourite international and local tourist attraction, partly owing to their easy access from Adnan Menderes Airport or from the cruise ship port of Kuşadası, some 30 km to the South.

The House of the Virgin Mary is a Catholic shrine located on Mt. Koressos in the vicinity of Ephesus, 7 kilometres from Selçuk in Turkey. The house was discovered in the 19th century by following the descriptions in the reported visions of Blessed Anne Catherine Emmerich (1774–1824), a Roman Catholic nun and visionary, which were published as a book by Clemens Brentano after her death. While the Catholic Church has never pronounced in favour or against the authenticity of the house, it nevertheless has maintained a steady flow of pilgrimage since its discovery. Anne Catherine Emmerich was Beatified by Pope John Paul II on October 3, 2004. Catholic pilgrims visit the house based on the belief that Mary, the mother of Jesus, was taken to this stone house by Saint John and lived there for the remainder of her earthly life. The shrine has merited several papal Apostolic Blessings and visits from several Popes John Paul II and Benedict XVI. On the way to the shrine, visitors pass a key hole-shaped baptismal pool, larger than the one located at the basilica in Ephesus. It is thought that an early community of Christians may have lived or were baptized here in seclusion in order to escape the nearby Romans. The shrine itself is not extensively large, but may rather be described as a modest chapel. The preserved stones and construction date back into the Apostolic Age, as consistent with other preserved buildings from that time, but with minor additions such as garden landscapes and devotional additions outside the shrine. Upon entrance to the chapel, a pilgrim is met by one single large room where an altar along with a large statue of the Blessed Virgin Mary is prominently displayed in the center. On the right side, a smaller room lies----traditionally associated with the actual room where the Virgin Mary is believed to have slept. Marian tradition holds that some form of running water used to flow like a canal in the smaller room where the Virgin Mary slept and rested, leading to the present drinking fountain outside the building structure.

Şirince (pronounced [ʃiˈɾindʒe]) is a village of 600 inhabitants in İzmir Province, Turkey, located about 8 kilometres (5.0 mi) east of the town Selçuk and about 8 kilometres from Ephesus. The area around the village has history dating back to Hellenistic period (323-31 BC). Pottery finds made around the village between 2001 and 2002 by Ersoy and Gurler indicate the presence of seven villages and nine farmsteads in the area dating back to ancient and medieval times. On the road up you will see the remains of several Roman aqueducts as the village was an important water source for ancient Ephesus. Today the village prospers through agriculture (olive oil, peaches, wine) and tourism. It is well protected and a rare and attractive example of Ottoman Christian archtectiture.