The museum is located in a medieval building, which encompasses the remains of a 15th century synagogue, which was right in the centre of the Jewish district in Lecce. Visitors to the museum can see the pools that were once used for ritual bathing (mikwa'ot), the doorpost groove that housed the sacred parchment with religious verses from the Scriptures (mezuzah), as well as significant remains of the church that partially incorporated the earlier synagogue. Visitors are invited to follow the threads linking the Jewish presence in Lecce and Salento from the Middle Ages up to the present day.